Investigation of correlation of bone metabolism index and BMD in 791 persons at the age groups from 35 to 79 years old in Changchun city

Objective To study the relationships between Bone mineral density(BMD) and serum levels of bone metabolism index including Tartrate-resistant acid phosphatase( TRACP),Collagen type Ⅰ carboxy-terminal peptide(CTX-1),Bone alkaline phosphotase(BALP),Calcitonin(CT),Bone Gla protein(BGP),Paratyroid hormone(PTH) and 25(OH) Vitamin D3 (25(OH) D3 ). Methods BMD at the one-third of distal Radius and ulna of non-dominant forearm was measured using DTX-200 detector made by American Osteometer Medi Tech Corporation; The bone metabolism index were measured by full-auto chemiluminescence analyzer(USA Beckmancoulter) and full-auto micro plate eia analyzer (USA Thermo). The 791 persons was didived into several groups by every five years. and then applied sofware SPSS 13. 0 to statistics data. Results The bone metabolism index such as TRACP,CTX-1,BALP,BGP were not statistically significant at gender among the age groups from 35 to 49 years old,but did among the age groups from 50 to 79 years old and the data of them in female was higher than them in male. The measure values of TRACP and CTX-1 were negative correlated with BMD;The measure values of BALP,BGP at the age groups from 50 to 64 yaers old was increased in female and were negative correlated with BMD,however,the measure values of them were decreased from 65 years old. The measure values of 25(OH)D3 was positive correlated with BMD;The measure values of CT was decreased in the age groups from 65 to 79 years old,and was positive correlated with BMD. Conclusion The test of bone metabolism index provided a significant technical method for monitoring bone mass and the earlier diagnosis of osteoporosis.