Eradication of Helicobacter pylori with levofloxacin sequential therapy

Objective To evaluate the eradication rate of ten days sequential therapy consisted of rabeprazole,amoxicillin,levofloxacin and furazolidone for Helicobacter pylori(Hp) infection.Methods Totally 88 Hp-infected patients with peptic ulcer or chronic gastritis diagnosed by gastroscopy were enrolled.These patients were randomly divided into trial group(n=44) and control group(n=44).Patients in trial group received rabeprazole,amoxicillin for the first 5 days,and followed by rabeprazole,levofloxacin and furazolidone for the last 5 days,and patients in control group received rabeprazole,clarithromycin and amoxicillin for 7 days.The status of Hp in patients of these two groups was compared after completion of treatment.Results The eradication rate of sequential therapy for ten days was 90.9% and that of control group was 75.0%.There was significant difference between these two groups(P0.05).Conclusion The 10-day sequential therapy comprising rabeprazole and levofloxacin can achieve a higher eradication rate of Hp.