To appraise sequential(including rabeprazole)therapy for eradication of helicobacter pylori

Objective To compare 10 days sequential(including rabeprazole、amoxillin、clarithromycin and levofloxacin)and 7 days traditional(including rabeprazole、amoxillin and clarithromycin)therapy for eradication of helicobacter pylori.Methods 193 patients with Hp positive peptic ulcer and chronic gastritis were randomly divided into two groups.102 patients were treated with rabeprazole,amoxillin at first five days,rabeprazole、clarithromycin and levofloxacin at the second five days.The control group(91 patients)were treated with rabeprazole、amoxillin and clarithromycin for seven days.Results The eradication rate of ten days sequential therapy was 96.1% and that of control group was 84.6%.The differences between two groups were significant(P0.05).Conclusion Ten days sequential therapy ismore effective,well-tolerated and with higher rate of eradication.