Meta analysis on the value of the hemoperfusion therapy in acute paraquat poisoning

Objective To elucidate the value of the hemoperfusion therapy in acute paraquat poisoning.Methods Pubmed,CNKI,Wangfang and VIP database were searched for the articles with paraquat and hemoperfusion as the key words.The relevant articles were reviewed.Qualified articles included those based on conventional medical treatment for the control group and hemoperfusion + conventional medical treatment for the study group.Results A total of 807 studies were included according to established search strategy,of which 10 were finally enrolled into the analysis,involving 690 subjects.In the study group,145 of the 330 patients died,with the mortality rate of 43.9%.In the control group,242 of the 360 patients died,with the mortality rate of 67.2%.One study was eliminated for its heterogeneity,and the rest 9 studies showed no heterogeneity(I2=0.00%,P=0.976,χ2=4.96).A fixed effect meta-analysis was used to analyze the difference in prognosis.Results showed that hemoperfusion+conventional medical treatment significantly improved the survival rate of acute paraquat poisoning(P0.001,RR=2.314,95%CI 1.81~2.9).Conclusion Hemoperfusion combined with conventional medical treatment could improve the prognosis and increase the survival rate for the patients with acute paraquat poisoning.