Clinical study of early high frequency oscillatory ventilation in the treatment of neonatal respiratory distress syndrome

Objective To investigate the ventilation effect and clinical efficacy of early high frequency oscillatory ventilation ( HFOV) in the treatment of neonatal respiratory distress syndrome ( RDS).Methods Forty-six children patients with RDS were randomly divided into two groups.Of them, 23 children patients were treated with HFOV (HFOV group) , 23 children patients with normal frequency mechanical ventilation (CMV) treatment ( CMV group).The lung function, the clinical efficacy and complications in two groups were compared.Results In HFOV group the arterial oxygen pressure ( PaO_2) and arterial carbon dioxide ( PaCO_2 ) underwent changes at 2 h of the treatment.After 6 h after treatment, oxygen concentration ( FiO_2), oxygenation index ( OI) were significantly decreased ; arterial/alveolar oxygen partial pressure ( a/APO_2 ) significandy increased.Compared with those before treatment there was a significant difference (P 0.01).In CMV group, compared with those before the treatment, there is a significant difference in PaO_2, PaCO_2 and OI and other indicators after 6 h of treatment ( P 0.05 ) ; When the treatment reached to the same time, HFOV group compared with the CMV group,there was significant difference in above indexes between two groups (P 0.05 or P 0.01).The incidence of bronchop ulmonary dysplasia ( BPD) and pulmonary barotrauma complications in HFOV group were lower than those in CMV group.There was significant difference (P 0.05 ).In survival children, the time of oxygen therapy and hospital stay in HFOV group were shorter than those in the CMV group, the difference was significant (P 0.05).Conclusion Compared with CMV,HFOV has advantages such as faster,and better, oxygenation improvement in children with RDS function, better ventilation effect, shortern course of disease, and less incidence of complications.It has good efficacy in the treatment of early RDS.