Treatment of Ectopic Pregnancy by Two Dosages of Methotrexate Combined with Mifepristone

Objective:To investigate the clinical efficacy and adverse reaction of two dosages of methotrexate(MTX) combined with mifepristone for treatment of ectopic pregnancy and guide clinical medication.Methods:128 patients with confirmed diagnosis of ectopic pregnancy were randomly divided into A and B group.64 patients in A group were given methotrexate 0.4 mg/(kg·d)intramuscular injection for 5 days combined with mifepristone tablets 25 mg taken by oral twice per day for 3 days.64 patients in B group were given a single intramuscular injection of MTX 1 mg/kg and mifepristone tablets 25 mg taken by oral twice per day for 3 days.The clinical efficacy and adverse reaction were observed and analyzed in two groups.Results:When the serum quantitation of β-HCG was 2000 U/L,the cure rate of ectopic pregnancy in group A was 98.43%,in group B was 95.31%.There was no significant difference (P0.05).The incidence of Ⅱ,Ⅲ degree of gastrointestinal reactions and decrease of blood cell count in group A was significantly higher than that in group B.There was significant difference(P0.05).Conclusions:It is a safe and effective method for the patients with ectopic pregnancy in lower levels of serum β-HCG by using a single injection of methotrexate 1mg/kg combined with mifepristone tablets 25mg taken by oral twice per day for three days.