The Adverse Reactions of Ectopic Pregnancy Treated with Methotrexate by Different Ways

Objective To investigate clinical efficacy and adverse reactions of methotrexate combined with mifepristone for non-ruptured ectopic pregnancy in different way.Methods 128 cases with ectopic pregnancy were randomly divided into two groups:the observation group,76 cases were treated with methotrexate 50～75 mg a single intramuscular injection plus mifepristone total of 300 mg,50 mg per injection by oral,every 12 hours.Control group,52 cases were treated with methotrexate 20 mg intravenous injection×5 days + mifepristone total of 300 mg,oral.Results The curative effect between the two groups had no statistical significace;comparison of adverse reactions between the two groups,there was a significant difference(P0.05).Among them,gastrointestinal reactions and oral ulcers were significant.Conclusion The two different drug treatments in the non-ruptured ectopic pregnancy are safe and effective,but the program of a single intramuscular methotrexate with little reaction in aspects of gastrointestinal reaction,bone marrow suppression,stomatitis.