Diagnostic value of IL-6 and CysC detection for diabetic kidney disease nephropathy in the early stage

Objective To explore the diagnostic value of interleukin-6(IL-6) and serum cystatin-C(CysC) detection for diabetic nephropathy in the early stage. Methods According to urinary albumin excretion rate(UAER),164 diabetic patients were divided into 2 groups.There were 120 diabetic patients without early renal damage(UAER20μg/min) in DM group;44 patients with diabetic nephropathy(UAER20-200μg/min) in DN group;while 50 healthy persons without diabetes served as the control group.IL-6 and CysC were measured in each group and analyzed statistically. Results Compared with control group,IL-6,CysC and hs-CRP levels were higher in DM and DN groups(P0.01);compared with DM group,the above three indexes were higher in DN group(P0.05).The positive rate of combined detection for early renal damage was significantly higher than that of the individual testing(P0.05);hs-CRP level in positive IL-6 and CysC group was higher than that in negative group(P0.01). Conclusion IL-6 and CysC detection are helpful to increase the positive rate of detection of diabetic nephropathy,has the important significance for early diagnosis of diabetic nephropathy.CysC and IL-6 detection has important value in judgment of disease activity.