Value of CysC and β_2-MG in early diagnosis of diabetic nephropathy

Objective To investigate the application value of CysC and β2-MG in early diagnosis of diabetic nephropathy(DN).Methods According to the urinary albumin excretion rate(UAER),90 cases of type 2 diabetes were divided into 3 groups,including normal,micro amount and large amount groups.Serum CysC,β2-MG,urea and Cr were parallelly detected and performed the comparative analysis in 102 cases of observation group and 43 cases of healthy control group.Results Compared with the healthy control group,the serum CysC,β2-MG in micro and large amount groups were significantly increased,but the difference between normal group and healthy control group had no statistical significance.The positive rate in large amount group were 100% and 100% respectively.The positive rate in micro amount group was CysC(95.2%) β2-MG(85.7%) Cr(45.2%) urea(30.9%).Conclusion Serum CysC and β2-MG have higher positive rates in diagnosing early DN,which can be used as early diagnostic marker of DN,especially CysC as ideal index.