Blood Glucose Levels and Severity of Coronary Stenosis in Hypertensive Patients

Objective To investigate the relationship between blood glucose levels and severity of coronary stenosis in hypertensive patients. Methods Blood pressure, fasting plasma glucose, 2 h plasma glucose, clinical features and coronary angiographic findings were analyzed retrospectively in 540 patients with essential hypertension. Acoording 2 h plasma glucose, patients were stratified into three group: group 1: 2h plasma glucose 7.8 mmol/L; group 2: 2 h plasma glucose 7.8-11.0 mmol/L;group 3: 2 h plasma glucose ≥11.1 mmol/L. The relation of coronary stenosis and blood glucose level was analyzed. Results The severity of the coronary stenosis was positively related to 2 h plasma glucose levels (P0.01). Mortality rate in 24 months was significantly higher in the group 3 (11.1%) than that in the group 1 (2.9%, P0.05). LVEF in the group 3 and group 2 were decreased(group 3: 53.8±9.9 and group 2: 54.1±10.2 vs group 1: 58.1±9.6,P0.05). Conclusion The severity of coronary artery stenosis and mortality rate were increased in hypertensive patients with the elevated glucose level.