Correlation of the angiography-confirmed coronary stenosis severity with blood glucose and function of pancreatic β cells

Objective To observe the association of the angiography-confirmed coronary stenosis severity with blood glucose and function of pancreatic β cells.Methods Oral glucose tolerance test (OGTT) and insulin releasing test(IRT) were done in 183 patients and all study patients underwent coronary angiography(CAG).Results The coronary angiography confirmed the coronary heart disease diagnosed by stenosis50%(CHD,n=118),coronary atherosclerosis diagnosed by stenosis≤50% (CA,n=38) and normal coronary artery(NCA,n=27).The oral glucose tolerance test showed 61 cases with diabetes mellitus(DM),54 cases with impaired glucose regulation(IGR) and 68 cases of normal glucose tolerance(NGT).Under the condition of FBG5.6 mmol/L,the 2h plasma glucose of IGT group and DM groups were positively correlated with severity of coronary lesions(P0.01),and HOMA-β was negatively correlated with severity of coronary lesion(P0.01).Under the condition of FBG5.6 mmol/L,2h-plasma gluose and HOMA-β were not correlated with coronary lesions severity(all P 0.05).Conclusion Under the condition of FBG5.6 mmol/L the 2h-plasma glucose in IGT and DM and HOMA-β are correlated with severity of coronary lesions.