The relationship between glucose tolerance and severity of coronary artery lesions in patients with coronary heart disease

Objective To elucidate the relationship between glucose tolerance and the severity of coronary artery lesions in patients with coronary heart disease. Methods Two hundred and seven patients with coronary heart disease were divided into 3 groups: 100 cases with normal glucose tolerance(NGT, group A) ; 47 cases with impaired glucose tolerance (IGT, group B); 60 cases with diabetes mellitus (DM, group C). All patients underwent coronary angiography and blood tests for fast blood glucose (FBG), postprandial 2h blood glucose (p2hBG), cholesterol(CHO), triglyceride (TG), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL). Results In 207 cases, patients coexisting glucose metabolic disorders account for 51.68%. The incidence of double and triple vessel lesions in group C(36.67% and 46.67%) were significantly higher than those in group B (29.79% and 31.91%) and group A (28.24% and 31.21%) (P0.05). There were no significant differences between group A and group B. Coronary artery lesion of group C was severer than that of group A and group B(P0.05) , but there was no significant difference between group A and group B. Diffuse lesion was more frequent in group C (63.33%) than group A(42.00%)and group B(36.17%)(P0.05) , also there was no significant difference between group A and group B. Conclusion The frequency of abnormal glucose metabolism is considerable high in patients with coronary heart disease. The coronary multivessel lesions and severe lesions and diffuse stenosis are more frequent in patients with diabetes mellitus.