Antibiotic resistance of 95 strains of Streptococcus pneumoniae isolates from children′s sputum

Objective:To analyse the antibiotic resistances of Streptococcus pneumoniae isolated from children and provide clinical guidelines for the rational use of antimicrobial agents.Methods:From September 2007 to December 2009,totally 95 clinical isolates of S.pneumoniae were used to determine the susceptibility of penicillin to 5 antimicrobial agents by K-B disk method,the MICs of oxacillin-resistant strains were performed byE-test.Results:The resistance rates of S.pneumoniae was relatively highly to erythromycin and clindamycin the resistance rates were 97.9%,96.8%.S.pneumoniae was vevry lower resistant to levofloxacin.No vancomycin-resistant strain was found.The isolation of PNSP was 58.9%,and the susceptibility of ceftriaxome was 98.7%.The ermB gene(98.9%) was predominant among isolates from children,while mefE was only 1.1%.Conclusion:The resistance of S.pneumoniae is serious in our hospital,and penicillin-nonsusceptible S.pneumoniae was increasing continuously,now was 58.9%.it is necessary to monitorits resistance of S.pneumoniae,and provide clinical guidelines for the rational use of antimicrobial agents.