Antibiotics susceptibility analysis of one hundred clinical streptococcus pneumoniae isolates

Objective:To investigate the in vitro antimicrobial susceptibility of Streptococcus pneumoniae and guide the rational use of drug clinically.Methods: Statistical analysis of the susceptibility of 100 strains of S.pneumoniae isolated was performed in our hospital from Feb.,2009 to Jan.,2010.Results: S.pneumoniae could be isolated from various specimens,most of them were isolated from sputum(96.0%).S.pneumoniae could be detected from many hospital wards,but more strains isolated from pediatric(85.0%) and respiratory(6.0%) departments.A total of 41.0% of S.pneumoniae isolates were penicillin non-susceptible,the resistance prevalence to erythromycin was 47.0%,totrimethoprim / sulfamethoxazole 42.0% and to Clindamycin 34%,while they were highly susceptible to vancomycin(95.0%),levofloxacin(90.0%),Ceftriaxone(83.0%) and lmipenem(83.0%).Conclusions: The resistance to penicillin of S.pneumoniae is serious in our hospital.The tetracycline and erythromycin are not the best choice in treating S.pneumoniae infection,and the new fluroquinolones show strong activity against S.pneumoniae.