Surveillance of antimicrobial resistance of Streptococcus pneumoniae in Qingdao area

ObjectiveTo investigate the antimicrobial resistance of Streptococcus pneumoniae in Qingdao area for rational use of antibiotics.MethodsFrom January 2003 to December 2004,effort was made to isolate S.pneumoniae from sputum and throat swab samples in 1 973 inpatients and outpatients.Dilution method and K-B disk method were used to determine the susceptibility of S.pneumoniae to 10 antimicrobial agents.ResultsOf 1 973 clinical isolates,107(5.4%) were S.pneumoniae.Forty-four of the 107(41.1%) S.pneumoniae isolates were not susceptible to penicillin,including resistant(n=22) and intermediate(n=22).The resistance rate of S.pneumoniae was relatively lower to cefotaxime,amoxicillin and chloramphenicol((15.0%,)(15.0%) and 13.1% respectively).S.pneumoniae was highly resistant to erythromycin,tetracycline and TMP-SMZ. The resistance rates were 73.8%,76.6% and 91.6% respectively.No vancomycin-resistant strain was found.ConclusionsPenicillin non-susceptible S.pneumoniae is highly prevalent in Qingdao area.The isolates of S.pneumoniae also show various level of resistance to other antibiotics except vancomycin.