Relationship between plasma homocysteine levels and the severity of coronary arterial lesions

Objective To investigate the relationship between plasma homocysteine(Hcy)levels and severity of coronary arterial lesion.Method Plasma Hcy were measured in157patients who had received coroˉnary angiography(CAG).The score for severity of coronary arterial lesions was assessed and patients were divided into coronary heart disease group and control group by CAG.Results Plasma Hcy of coronary heart disease group was significantly higher than that of control group(t=3.23,P0.01).Hcy level in triple-vessel group or double-vessel group was significantly higher than that in the controls(t=-2.03,P0.05;t=-2.57,P0.05).There was not significant difference between the single vessel group and control group(P0.05).By analyzing single factor correlation,Hcy positively correlated with coronary arterial lesion score,number of involved branch,age(r=0.26,r=0.25,r=0.31,P0.01,P0.01,P0.05respectively).Logistic regression found that Hcy,age,hypertension and diabetes mellitus are risk factors of coronary heart disease.Conclusion Hcy is possible directly related to the severity of coronary arterial lesions and may be a new independent risk factor for coronary heart diseases.