Application of Combined Detection of Three Markers in Assessment of Acute Coronary Syndromes

To evaluate clinical significance of three cardiac markers including cardiac troponin I(cTnI),C-reactive protein(CRP),and B-type natriuretic peptide(BNP) in acute coronary syndromes(ACS),cTnI,CRP,and BNP levels were measured by CLIA of cTnI,by partical enhanced immunoturbidimetric assay of CRP,and by micropartical EIA of BNP in 176 patients with ACS.Results showed that sensitivity and specificity of cTnI were 100% and 96.9% in early clinical classification.Each and every cTnI,CRP,and BNP might be regarded as independent predictors of patients with ACS.In risk ratios of major cardiac events about death,myocardial infarction,or congestive heart failure,two elevated markers had 1.95,1.31 or 1.33 fold increase than those with one elevated marker respectively,and three elevated markers had 4.88,1.47,or 4.07 fold increase than those with one elevated marker respectively.cTnI was confirmed the powerful role in early clinical classification.Simultaneous assessment of cTnI,CRP,and BNP in patients with ACS could provide much more risk stratification information on major cardiac events.