2004•Journal of Apoplexy and Nervous DiseasesRequires access

Protective effects of PTS on cerebral ischemia-reperfusion injury in rats

Zhou Demin

Abstract

Objective To study the protective effects of PTS on cerebral ischemia-reperfusion injury in rats.Metheods The model of acute reperfusion injury after cerebral ischemia in rats was made bymiddle cerebral artery occlusion.6d before operation and 2h pre occlusion,the rats received intraperitoneally PTS(50 mg/kg) or normal saline injection respectively,then all the animals were allowed 2h ischemia and sacrificed after different durations of reperfusion (3h,6h,24h,48h,72h,7d).The neurological deficitgrades and the volume of the cerebral infarction were estimated by 2% TTC staining and Zea Longa's method.Results The data showed non-significant differences on the neurological deficit scores between the control and PTS-treated groups (50mg/kg) except for at 72h after reperfusion.The cerebral infarct sizes of the forebrain in the PTS-treated groups except for (3h and 6h) of reperfusion reduced significantly compared with the control groups.Conclusion PTS possesses cerebral protective effects against ischemia-reperfusion injury.

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Key concepts: Medicine, Ischemia, Reperfusion injury, Anesthesia, Saline, Neurological deficit, Occlusion, Cerebral infarction