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Determination of scopoletin in Dinggongteng injection by HPLC

Meijuan Wang

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Abstract

Objective:To develop a method for the determination of scopoletin in Dinggongteng injection by HPLC.Methods: The Sunfire column(4.6 mm×150 mm,5 μm) was used with methanol-acetonitrile-acetic acid(320∶680∶1.6) as the mobile phase.The flow rate was 1.0 mL·min-1,the detection wavelength was 298nm.Results: A good linearity was obtained when the injected quantity was in the range of 20~60 μg(r=0.9983,n=5).The recovery was 96.8%,and RSD was 1.6%.Conclusion: This method is convenient,accurate and reliable for the determination of this injection.

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What this paper is about

Objective:To develop a method for the determination of scopoletin in Dinggongteng injection by HPLC.Methods: The Sunfire column(4.6 mm×150 mm,5 μm) was used with methanol-acetonitrile-acetic acid(320∶680∶1.6) as the mobile phase.The flow rate was 1.0 mL·min-1,the detection wavelength was 298nm.Results: A good linearity was obtained when the injected quantity was in the range of 20~60 μg(r=0.9983,n=5).The recovery was 96.8%,and RSD was 1.6%.Conclusion: This method is convenient,accurate and reliable for the determination of this injection.

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Available abstract

Objective:To develop a method for the determination of scopoletin in Dinggongteng injection by HPLC.Methods: The Sunfire column(4.6 mm×150 mm,5 μm) was used with methanol-acetonitrile-acetic acid(320∶680∶1.6) as the mobile phase.The flow rate was 1.0 mL·min-1,the detection wavelength was 298nm.Results: A good linearity was obtained when the injected quantity was in the range of 20~60 μg(r=0.9983,n=5).The recovery was 96.8%,and RSD was 1.6%.Conclusion: This method is convenient,accurate and reliable for the determination of this injection.

Key concepts: Scopoletin, Chromatography, Chemistry, High-performance liquid chromatography, Acetic acid, Acetonitrile, Methanol, Medicine

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