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Double-blind comparision of sertraline and amitriptyline in treatment for senile depressive disorder

Ping Wang

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Abstract

Objective To appraise the efficacy and side effects of sertraline in treatment of senile depressive disorder.Method Thirty seven senile patients with depressive disorder were treated with sertralin and amitriptyline respectively.The therapeutic effects of sertraline were compared with amitriptyline in the double-blind controlled study using HAMD,CGI and TESS.Results There was no significant difference in the reduction of HAMD and CGI in both groups.The incidence of cholinergic effect of sertraline was less than that of amitriptyline.Conclusion Sertraline is an effective antidepressant for senile depressive disorder,and its therapeutic effects(P0.01) is comparable with amitriptyline with less side effects.

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Objective To appraise the efficacy and side effects of sertraline in treatment of senile depressive disorder.Method Thirty seven senile patients with depressive disorder were treated with sertralin and amitriptyline respectively.The therapeutic effects of sertraline were compared with amitriptyline in the double-blind controlled study using HAMD,CGI and TESS.Results There was no significant difference in the reduction of HAMD and CGI in both groups.The incidence of cholinergic effect of sertraline was less than that of amitriptyline.Conclusion Sertraline is an effective antidepressant for senile depressive disorder,and its therapeutic effects(P0.01) is comparable with amitriptyline with less side effects.

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Available abstract

Objective To appraise the efficacy and side effects of sertraline in treatment of senile depressive disorder.Method Thirty seven senile patients with depressive disorder were treated with sertralin and amitriptyline respectively.The therapeutic effects of sertraline were compared with amitriptyline in the double-blind controlled study using HAMD,CGI and TESS.Results There was no significant difference in the reduction of HAMD and CGI in both groups.The incidence of cholinergic effect of sertraline was less than that of amitriptyline.Conclusion Sertraline is an effective antidepressant for senile depressive disorder,and its therapeutic effects(P0.01) is comparable with amitriptyline with less side effects.

Key concepts: Amitriptyline, Sertraline, Hamd, Antidepressant, Medicine, Major depressive disorder, Internal medicine, Psychology

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