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2008•Medical Journal of Chinese People's HealthRequires access

A Comparative Study of Sertraline and Amitriptyline in the treatment of Depressive Disorder

Shusheng Li

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Abstract

Objective:To investigate the anti-depressive effect and adverse effects of Sertraline and Amitriptyline to treat depressive disorders. Methods:52 patients with depressive disorders to accord with the CCMD-3 were enrolled. The examples were random to divide in treatment Sertraline and Amitriptyline. Hamilton Rating Scale of Depression (HAMD), Clinical Global Impression (CGI) and Treatment Emergent Symptom Scale (TESS) were used to evaluate the changes clinical symptoms and side effects at baseline, after treatment one week, two weeks, four weeks and six weeks respectively.Results: There are not significant differences in CGI and HAMD scores between two groups (P0.05). Sertraline was quicker than Amitriptyline in the anti-depressive effect and that has less side effects than Amitriptyline (P0.01).Conclusions: The results suggested the Sertraline was a new safe and effective anti-depressant.

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What this paper is about

Objective:To investigate the anti-depressive effect and adverse effects of Sertraline and Amitriptyline to treat depressive disorders. Methods:52 patients with depressive disorders to accord with the CCMD-3 were enrolled. The examples were random to divide in treatment Sertraline and Amitriptyline. Hamilton Rating Scale of Depression (HAMD), Clinical Global Impression (CGI) and Treatment Emergent Symptom Scale (TESS) were used to evaluate the changes clinical symptoms and side effects at baseline, after treatment one week, two weeks, four weeks and six weeks respectively.Results: There are not significant differences in CGI and HAMD scores between two groups (P0.05). Sertraline was quicker than Amitriptyline in the anti-depressive effect and that has less side effects than Amitriptyline (P0.01).Conclusions: The results suggested the Sertraline was a new safe and effective anti-depressant.

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Available abstract

Objective:To investigate the anti-depressive effect and adverse effects of Sertraline and Amitriptyline to treat depressive disorders. Methods:52 patients with depressive disorders to accord with the CCMD-3 were enrolled. The examples were random to divide in treatment Sertraline and Amitriptyline. Hamilton Rating Scale of Depression (HAMD), Clinical Global Impression (CGI) and Treatment Emergent Symptom Scale (TESS) were used to evaluate the changes clinical symptoms and side effects at baseline, after treatment one week, two weeks, four weeks and six weeks respectively.Results: There are not significant differences in CGI and HAMD scores between two groups (P0.05). Sertraline was quicker than Amitriptyline in the anti-depressive effect and that has less side effects than Amitriptyline (P0.01).Conclusions: The results suggested the Sertraline was a new safe and effective anti-depressant.

Key concepts: Sertraline, Amitriptyline, Hamd, Clinical Global Impression, Depression (economics), Major depressive disorder, Rating scale, Medicine

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