The value of serum β_2-MG and LDH in judging non-Hodgkin's lymphoma treatment

Objective To explore the relationship of serum β2-microglobulin(β2-MG) and lactate dehydrogenase(LDH) and the clinical features and prognosis of non-Hodgkin's lymphoma.Methods All 62 cases of non-Hodgkin's lymphoma patients,according to the clinical symptoms were divided into A,B groups,according to bone marrow smears were divided into a shower of white group,bone marrow infiltration and without bone marrow infiltration group.Each group were compared and the different prognosis of serum β2-MG and LDH levels.Results The differences of serum β2-MG and LDH level between the different clinical stages were significant(P 0.01);serum β2-MG,and LDH levels of group B were significantly higher than group A(P 0.01).The serum β2-MG,LDH level among cream white group,bone marrow infiltration group and no bone marrow infiltration were significantly different(P 0.01).Different effects between the groups in serum β2-MG,LDH level difference were significant before and after treatment,after treatment,serum β2-MG and LDH level of the CR group and PR group were significantly lower than before(P 0.01).The area of β2-MG and LDH under the ROC curve were 0.911,0.924(P 0.05).Conclusion The serum β2-MG and LDH are closely related to clinical symptoms,clinical stage,bone marrow infiltration and efficacy in non-Hodgkin's lymphoma,and could judge the efficacy of clinical indicators.