Expression of HER-2,P53,Ki-67,Nm23,ER and PR Proteins in Breast Cancer and Their Clinical Significance

To investigate the expression characteristic of human epidermal growth factor receptor(HER-2),P53,Ki-67,Nm23,estrogen receptor(ER) and progesterone receptor(PR) proteins in invasive duct carcinoma of breast,and analyze their correlation and clinical significance,the SP immunohistochemical technique was used to determine HER-2,P53,Ki-67,Nm23,ER,and PR proteins expression in 73 patients with breast cancer.The relationships between the expression of proteins and the clinical and pathological data of patients were retrospectively analyzed.The results showed that the expression rate of HER-2,P53,Ki-67,Nm23,ER,and PR proteins in patients were 47.9%,69.9%,87.7%,84.9%,60.3%,and 56.2% respectively.The expression of six proteins was not significantly correlated with the patient age,the tumor size,the axillary lymph node metastasis,and the history grade(P0.05),exception of HER-2 with the axillary lymph node metastasis(P0.05).The expression of PR was significantly positive correlated with ER,ER and P53(P0.05).The expression of PR was significantly negative correlated with Ki-67,ER and HER-2(P0.05).HER-2 over-expression is maybe a significant molecular marker for detection of breast cancer,and the combination of HER-2 with hormone receptor,Ki-67 and P53 expressions could be used to evaluate clinical prognosis and select therapeutic options.