ANALYSIS OF THE DISTRIBUTION AND ANTIBIOTIC RESISTANCE OF GRAM-NEGATIVE BACILLI IN INTENSIVE CARE UNIT

Objective To investigate the distribution and drug resistance of common gram-negative bacilli isolated in ICU,and provide reference for clinical anti-infective therapy. Methods A retrospective review was done for gram-negative bacilli isolated from samples of 198 patients,treated in ICU from Jun 2008 to Jun 2011,in terms of their distribution and drug resistance. Results A total of 491 strains of gram-negative bacilli were isolated,which were mainly consisted of enteric bacilli and non-fermentative gram-negative bacilli.Of the 491 strains isolated,the first five detection rates were in order of Acinetobacter baumannii 143 strains(29.12%),Escherichia coli,98(19.96%),Pseudomonas aeruginosa 95(19.35%),Klebsiella pneumonia 75(15.27%),and Proteus mirabilis 22(4.48%).Of the strains isolated,more than 50% were from respiratory tract,which were generally resistant to commonly used antibiotics,40 strains were pan-resistant,of which,40 strains were Acinetobacter baumannii and three were Pseudomonas aeruginosa. Conclusion Gram-negative bacillus is a strain that commonly infects patients in ICU,which has a higher drug resistance to frequently used antibiotics,more with multidrug resistance,a monitoring of the resistance should be enhanced.