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ADR Cases Report of Our Hospital in 2004～2006:An Analysis of 412 Cases

Kainan Liu

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Abstract

OBJECTIVE:To explore the factors,general rule and characteristics of adverse drug reactions(ADR)for references of safe and rational clinical medication.METHOD:A total of 412 ADR reports were collected and statistically analyzed in respect of age and sex of patients,route of administration,ADR degree,drug category,ADR-involving organs and clinical manifestations etc.RESULTS:ADR-involving drugs totaled 412 kinds,of which anti-infective agents occupied the first place,followed by Chinese patent medicines.274 ADR cases(66.50%)were induced by intravenous route.ADR occurred systemically and were characterized predominantly by allergic reactions of skin and its appendants,followed by damage of nervous system.70 were new but common ADR cases,while 2 were new severe cases.CONCLUSION:It is necessary to strengthen ADR monitoring and publicizing of ADR-related knowledge to guide the clinical rational use of drugs and reduce the repetitive occurrence of ADR.

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OBJECTIVE:To explore the factors,general rule and characteristics of adverse drug reactions(ADR)for references of safe and rational clinical medication.METHOD:A total of 412 ADR reports were collected and statistically analyzed in respect of age and sex of patients,route of administration,ADR degree,drug category,ADR-involving organs and clinical manifestations etc.RESULTS:ADR-involving drugs totaled 412 kinds,of which anti-infective agents occupied the first place,followed by Chinese patent medicines.274 ADR cases(66.50%)were induced by intravenous route.ADR occurred systemically and were characterized predominantly by allergic reactions of skin and its appendants,followed by damage of nervous system.70 were new but common ADR cases,while 2 were new severe cases.CONCLUSION:It is necessary to strengthen ADR monitoring and publicizing of ADR-related knowledge to guide the clinical rational use of drugs and reduce the repetitive occurrence of ADR.

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Available abstract

OBJECTIVE:To explore the factors,general rule and characteristics of adverse drug reactions(ADR)for references of safe and rational clinical medication.METHOD:A total of 412 ADR reports were collected and statistically analyzed in respect of age and sex of patients,route of administration,ADR degree,drug category,ADR-involving organs and clinical manifestations etc.RESULTS:ADR-involving drugs totaled 412 kinds,of which anti-infective agents occupied the first place,followed by Chinese patent medicines.274 ADR cases(66.50%)were induced by intravenous route.ADR occurred systemically and were characterized predominantly by allergic reactions of skin and its appendants,followed by damage of nervous system.70 were new but common ADR cases,while 2 were new severe cases.CONCLUSION:It is necessary to strengthen ADR monitoring and publicizing of ADR-related knowledge to guide the clinical rational use of drugs and reduce the repetitive occurrence of ADR.

Key concepts: Medicine, Drug reaction, Adverse drug reaction, Drug, Intravenous route, Route of administration, Pharmacology, Internal medicine

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