Prediction value of serum C-reactiveprotein, serum amyloid A, and interleukin-6 in acute coronary syndrome

Objective: To investigate the difference and relationships of serum C-reactive protein (CRP), serum amyloid A (SAA), and interleukin-6 (IL-6)levels in different subtype of coronary heart diseases and explore the potential predicting factors for the acute coronary syndrome(ACS). Method:The levels of serum CRP,SAA,IL-6 in 32 acute myocardial infarction(AMI), 30 unstable angina pectoris(UAP), 20 stable angina pectoris(SAP) and 16 normal healthy control subjects were measured by enzyme-linked immunosorbent assay, comparing the values of CRP, SAA, IL-6 among different. Result:Serum CRP,SAA,IL-6 levels were significantly higher in the ACS group compared with normal group. They were (6.94±4.56)∶(2.48±2.32)mg/L; (217.23±441.14)∶(18.18±28.05)mg/L; (4.37±6.35)∶(1.31±0.98)ng/L.(P0.01).CRP, SAA, IL-6 levels were positively correlated with each other. For ACS, the sensitivity was 73.8%, specificity was 91.7%, accuracy was 80.4% with serum CRP,SAA,IL-6 levels. Conclusion:The elevated SAA,CRP, IL-6 levels suggested an obvious relationship with pathogenesis of ACS, which may be a potential markers of plaque instability and were regarded as the markers for early diagnosis of ACS.