Clinical effect of adefovir dipivoxil combined with oxymatrine on patients with chronic hepatitis B with HBV-YMDD mutation

OBJECTIVE To study the effect and safety of adefovir dipivoxil combined with oxymatrine on patients with HBV-YMDD mutation after treatment of lamivudine.METHODS Eighty patients with chronic hepatitis B with HBV-YMDD mutation after treatment of lamivudine were chosen.All patients were HBeAg positive,liver function abnormal before this study.All patients with adefovir dipivoxil combined with oxymatrine were treated for more than 12 months.HBV-DNA,Alanine aminotransferase(ALT) and HBeAg were assayed to observe the effect and safety of this therapy.RESULTS After the patients were given adefovir dipivoxil combined with oxymatrine for 3,6 and 12 months,the negative rate of HBV-DNA were 30.67%,46.83%,and 61.67%,respectively;the rate of normal level of ALT were 48.06%,63.71%,and 80.45%,respectively;the negative rate of HBeAg were 15.83%,27.5%,34.17%,respectively.There was no any significant renal toxicity and drug resistant mutation in patients.CONCLUSION Adefovir dipivoxil combined with oxymatrine is effect on patients with chronic hepatitis B with HBV-YMDD mutation.