The clinical study on the effects of adefovir dipivoxil combined with oxymatrine in patients with chronic hepatitis B

Objective To explore the effects of adefovir dipivoxil combined with oxymatrine in patients with chronic hepatitis B.Methods All selected cases of chronic hepatitis B were at random assigned into two groups.In observed group,adefovir dipivoxil was given 10 mg once a day and oxymatrine 0.4～0.6/d intravenously or intramuscularly for 24 weeks.In controlled group,adefovir dipivoxil was given alone.At the end of the therapy,the response were observed.Results At the end of 24 week therapy,the rates of virological,chemical,serological and complete responses in the two groups were 67.1% and 50.0%,78.6% and 58.9%,30.4% and 11.5%,and 27.1% and 13.2%,respectively(P= 0.0359,0.0076,0.0205 and 0.0344,respectively.) Conclusion The combination treatment with adefovir dipivoxil and oxymatrine is an effective treatment for patients with chronic hepatitis B,and oxymatrine can enhance the effect of adefovir dipivoxil on anti-HBV capacities.