2008•Journal of Taishan Medical CollegeRequires access

The clinical study of Acertil in treating congestive heart failure

Zhou Fa-zhan

Abstract

Objective: To investigate the clinical study of Acertil(Perindopril) in treating congestive heart failure.Methods: 118 patients,who had unsatisfactory results under conventional Digitoras,Diuretics,Vasodilators therapy,were given Acertil 2 ~4 mg orally once a day for 4 ~6 weeks.The changes of heart rate(HR),blood pressure(BP),cardiothoracic ratio,left ventricular and diastolic diameter(LVDd),left ventricular ejection fraction(LVEF) and cardiac function(NYHA) were observed.Results: After 4 ~6 weeks by the therapy,HR BP cardiothoracic ratio and LVDd all decreased significantly(P0.05);LVEF increased(P0.05);Cardiac function(NYHA) improved by 1 ~2 grade.Acertil had few adverse effects and patients tolerance was perfect.Conclusion: The effect of Acertil in treating congestive heart failure is satisfactory.Acertil has little adverse effect and is effective for congesitive heart failure.

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Key concepts: Medicine, Heart failure, Cardiology, Ejection fraction, Internal medicine, Perindopril, Cardiac function curve, Diastole