2007•Zhongguo linchuang baojian zazhiRequires access
The effects of carvedilol on heart function and neurohormones in patients with congestive heart failure
Xu Yong
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Abstract
Objective To investigate the effects of Carvedilol on heart function and neorohormones in patients with congestive heart failure(CHF) by double-blind randomized clinical trial.Method40 congestive heart failure patients were double-blind randomly divided into two groups,20 of them randomized to Carvedidilol with routine therapy group and 20 patients to Placebo with routine therapy group.The change of heart rate,blood pressure,NYHA classification,6 min.walk distance,left ventricular ejection fraction(LVEF) and left ventricular diastolic dimension(LVDd) by 2-D Echocardiography were observed before and 1、3 months after treatment,meanwhile the plasma concentration of norepinephrine,renin and angiotensin II in patients who were supine position were measured in the morning before and 6 weeks after treatment.ResultsThe study showed the patients' heart rate,blood pressure,NYHA classification,6 min.walk distance,LVEDd,LVEF significantly improved.The plasma concetration of norepinephrine,renin,angiotensin II in patients with CHF were higher than those of healthy control group(P0.01),and signicantly reduced(P0.01) after treatment with Carvedilol compared with routine treatment.No patient died and had heart failure worsened in carvedilol group,but 6 patients were rehospitalized because of worsening heart failure in Placebo group.ConclusionIt was indicated that Carvedilol could signicantly improve heart function and reduce the plasma concentration of neurohormones in patients with congestive heart failure.