Correlation of HPV infection and cervical lesions in Luzhou area of Sichuan

Objective To investigate the relationship between multiple human papillomavirus(HPV)infection and cervical lesions in Luzhou area of Sichuan.Methods The cervical smear and paraffin tissue samples of 795women were analyzed by HPV gene microarray technology,the multiple infection status and subtypes of HPV in different cervical lesions were investigated.Results A total of 795samples were collected in this study,435cases were with HPV infections(54.7%).The HPV positive rate showed an ascending trend with the severity of cervical lesions(P0.05).Multiple HPV infection rate was42.8%(186/435).The rate of multiple HPV infections in chronic cervicitis,CINI,CINII,CINIII,cervical papilloma-like lesions and cervical cancer were 35.5%(60/169),44.9%(22/49),47.8%(22/46),50.0%(25/50),45.8(11/24),47.4%(46/97),respectively.There was no significant difference in the rate of multiple infections among different cervical lesion groups(P0.05).There was no significant difference in the rate of a single type(high-risk or low-risk)of HPV infection and multiple types(high-risk or low-risk)of HPV infection among all kinds of cervical lesions(P0.05).Conclusion The multiple HPV infection rate in Luzhou area is high.The severity of cervical lesions is closely related to infection rate of HPV,depending on the pathogenicity of HPV subtypes rather than quantity of HPV subtypes.More attention should be paid to prevent cervical cancer when infected with high-risk HPV subtypes.