Study of ulinastatin against gastrointestinal complications in patients with septic shock

Objective:To evaluate the effect of ulinastatin against gastrointestinal complications in patients with septic shock.Methods:Seventy-six patients with septic shock were randomly divided into two groups:treatment group(n=38)and control group(n=38).All patients in two groups were treated according to the Guardline of 2004 for rescuing severe septic shock.The patients in treatment group received intravenous ulinastatin of 200 000 U once every eight hours for one week in addiction to routine treatment.Results:In comparison with control group,the occurrence of toxic ileus,stress ulcer,MODS and mortality decreased obviously(P0.05)in treatment group.Conclusion:Tryspin inhibitor(ulinastatin)can reduce the occurrence of gastroparesis,toxic ileus,stress ulcer,superinfection,MODS and mortality in patients with septic shock.