2018•国际医药卫生导报Requires access
Clinical study on ulinastatin combined with CRRT in the treatment of elderly patients with septic shock
Ruijian Wu, Decheng Gong, Qiang Wang
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Abstract
Objective
To investigate the value of ulinastatin combined with continuous renal replacement therapy (CRRT) in the treatment of senile septic shock.
Methods
Seventy-two elderly patients with septic shock from January 2017 to March 2018 were enrolled and were divided into observation group and control group according to the random number table method, 36 cases in each group. On the basis of conventional treatment, the control group was treated with CRRT, and the observation group was treated with ulinastatin + CRRT. Serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] levels and the severity of disease were compared between the two groups before treatment and 7 days after treatment. The mortality of the two groups were statistically compared.
Results
There were no statistically significant differences in serum IL-6, TNF-α levels, and APACHE II score between the two groups before treatment (P>0.05); after 7 days of treatment, serum IL-6, TNF-α levels, and APACHE II score in the observation group were lower than those in the control group (P 0.05).
Conclusion
Ulinastatin combined with CRRT in the treatment of senile septic shock can effectively reduce the body's inflammatory response, relieve the severity of the disease, with low mortality rate.
Key words:
Septic shock; Continuous renal replacement therapy; Ulinastatin; Inflammatory factor