The clinical observation of high-dose ulinastatin in septic shock

Objective To explore the clinical effect of high-dose ulinastatin in septic shock.Methods 36 cases patients with septic shock were randomly divided into treatment group and control group,each of 18 cases.On the basis of conventional therapy,treatment group were given ulinastatin 200 000U+normal saline 30ml intravenous injection,and then ulinastatin 1 million U continuous micro-pump pump,speed of 50 000U/h,conjunction 7d.Control group received conventional therapy.After treatment,compared a variety of indicators of inflammation and multiple organ dysfunction syndrome(MODS) incidence.Results After treatment 3d body temperature,respiration,heart rate,white blood cell count,high-sensitivity C-reactive protein and other inflammatory indicators of two groups were improved(P0.05);After treatment 3d,breathing,heart rate,white blood cell count,high sensitivity C-reactive protein of treatment group were better than those of control group,the difference were statistically significant(P0.05);The MODS incidence of treatment group(33.3%) was lower than that of control group(61.1%),the difference was statistically significant(P0.05).Conclusion High-dose ulinastatin can effectively reduce inflammatory response in patients with septic shock and the incidence of MODS.