Clinical study of ulinastatin on lung injury in patients with septic shock

Objective:To observe the effects of Ulinastatin on lung injury in patients with septic shock complicating with ALI or ARDS,and explore its mechanisms.Methods: Patients with septic shock complicating with ALI or ARDS were randomly divided into two groups: group A was treatment group(n=42),group B control group(n=42),who were treated according the Guideline of Rescuing Severe Septic Shock and the Guideline of the Diagnosis and Therapy for ALI/ARDS.The patients in group A received Ulinastatin 200,000 units intravenous every eight hours for one week.Parameters of arterial blood gas,oxygenation index(PaO2/FiO2),acute physiology and chronic health evaluation-Ⅱ(APACHE-Ⅱ) score and lung injury Murray's score were measured respectively,and the rate of MODS and mortality were calculated.Results: In comparison with control group,PaO2/FiO2,APACHE-Ⅱscore and the rate of MODS improved obviously(P0.05),lung injury Murray's score and mortality didn't decrease obviously(P0.05) in treatment group.Conclusion: Trypsin inhibitors—Ulinastatin can mitigate lung injury,protect lung function and reduce the occurrence of MODS in patients with septic shock complicating with ALI or ARDS.