Clinical observation on adefovir dipivoxil combined with Gansu capsule for active liver cirrhosis

Objective To investigate the efficacy and safety on Adefovir Dipivoxil combined with Gansu capsule in treatment of active liver cirrhosis.Methods 87 patients with active hepatitis B together with liver cirrhosis were randomly divided into 49 cases of the treatment group and the control group of 38 cases.The two groups were given Adefovir Dipivoxil 10mg/d treatment on the basis of the conventional therapy such as the liver protection,and expectant treatment.The treatment group was treated with Gansu capsule three times daily on the basis of control group,three pieces once,24-week-course of treatment.Results Child-Pugh score of the two groups decreased,liver function and liver fibrosis index was improved,HBV-DNA load declined,the value of spleen thickness decreased,and the difference of comparison was significant(P0.01 or P0.05);the treatment group was superior to the control group(P0.01 or P0.05)after the treatment.Conclusion Adefovir Dipivoxil combined with Gansu capsule in treatment of active liver cirrhosis of hepatitis B can make a significant therapeutic effect on active liver fibrosis and can coordinatly improve liver function,and can supply security in clinical application.