Adefovir Dipivoxil Combined with Dahuangzhechong Pill in the Treatment of Cirrhosis Secondary to Hepatic B

Objective:To observe the therapeutic effect of Adefovir dipivoxil combined with Dahuangzhechong Pill in the treatment of the patients with cirrhosis secondary to active hepatitis B.Methods:45 patients with compensated cirrhosis secondary to active hepatitis B(child-pughintegral≤7') were randomly divided into two groups.The control group(involved 22 cases) treated with Adedovir dipivoxil and the treatment group(involved 23 cases) was given Adefovir dipivoxil combined with Dahuangzhechong Pill.Changes in the serum level of HBV-DNA,transaminoase,liver fibrosis indexes and child-pugh integral were compared with each other and inner diameter of portal vein as well as thickness of the spleen were measured by B ultrasonography before and after treatment.Results:Serum liver fibrosis parameters in treatment group declined significantly than that in control group.The inner diameter of portal vein and thickness of the spleen were averagely decreased in treatment group.There was significant difference with that in control group after treatment.Negative conversion rates of HBV-DNA were similar between the two groups.Normalization rates of transaminoase of treatment group was higher than that of control group.Conclusion:Adedovir dipivoxil combined with Dahuangzhechong Pill can better control the hepatitis activity and prenvent the development of liver cirrhosis.