The Expression of p16 and Cyclin D1 in Proliferative Endometrium and Endometrial Carcinoma

Objectives:To study the role of p16 and cyclinD1 in the genesis and development of endometrial carcinoma.Methods:12 cases of normal endometrium,22 cases of proliferative endometrium and 41 cases of endometrial carcinoma were detected for the expression of p16 and cyclinD1 by means of immuniohistochemical S-P. Results:Among the groups of the simple and compound hyperplasia,the atypical hyperplasia and the endometrial carcinoma,p16 showed a descending tendency ,while the expression of cyclinD1 showed an ascending tendency.In endometrial carcinomas,the expression of p16 was significantly lower than normal endometrium and proliferative endometrium( P 0.01, P 0.05).However,the expression of cyclinD1 in proliferate endometrium and endometrial carcinoma was significantly higher than that in normal endometrium( P 0.05, P 0.01).The overexpression of cyclinD1 in the atypical hyperplasia group was obviously different from that in the simple and compound hyperplasia proup( P 0.01).In endometrial carcinoma,the expression of p16 was decreasing with the descending of cell differentiate degree,on the opposite,the expression of cyclinD1 was increasing,which indicated a negative correlation between them.Conclusions:The aberrant expression of p16 cyclinD1 was involved in the genesis of endometrial carcinoma;The low expression of p16 and the over expression of cyclinD1 correlate with the malicious biological behaviors of endometrial carcinoma;Over expression of cyclinD1 may be an earlier molecular event.