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Determination of Ginkgolides in Ginkgo Biloba Extract from Guizhou by High-performance Liquid Chromatography

Jiang Cuihong

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Abstract

Objective To develop a method for measurement of ginkgolide A,B,C,Bilobalide in the Ginkgo biloba extract from Guizhou Province.MethodsThe Ginkgo biloba leaves was extracted with methanol and gradient elution.ResultsThe theoretical plate number of Ginkgolide was 6088,the resolution was 1.42 and the tailing factor was 1.01.The Intra-day and inter-day precision(RSD) were all less than 1.5%,while the recurrence(RSD) was 0.65%(n=5).The limit of detection was 0.5μg/ml,the average recovery rates were 97.7%,97.2%,94.7% and 94.6%.ConclusionOur developed method can shorten the time used for Ginkgo biloba leaves pretreatment,and is a simple and reliable method to determine the content of ginkgolied A,B,C and Bilobalide in the Ginkgo biloba extract.The results also prove that the quality of Ginkgo biloba in Guizhou Province is relatively good.

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What this paper is about

Objective To develop a method for measurement of ginkgolide A,B,C,Bilobalide in the Ginkgo biloba extract from Guizhou Province.MethodsThe Ginkgo biloba leaves was extracted with methanol and gradient elution.ResultsThe theoretical plate number of Ginkgolide was 6088,the resolution was 1.42 and the tailing factor was 1.01.The Intra-day and inter-day precision(RSD) were all less than 1.5%,while the recurrence(RSD) was 0.65%(n=5).The limit of detection was 0.5μg/ml,the average recovery rates were 97.7%,97.2%,94.7% and 94.6%.ConclusionOur developed method can shorten the time used for Ginkgo biloba leaves pretreatment,and is a simple and reliable method to determine the content of ginkgolied A,B,C and Bilobalide in the Ginkgo biloba extract.The results also prove that the quality of Ginkgo biloba in Guizhou Province is relatively good.

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Available abstract

Objective To develop a method for measurement of ginkgolide A,B,C,Bilobalide in the Ginkgo biloba extract from Guizhou Province.MethodsThe Ginkgo biloba leaves was extracted with methanol and gradient elution.ResultsThe theoretical plate number of Ginkgolide was 6088,the resolution was 1.42 and the tailing factor was 1.01.The Intra-day and inter-day precision(RSD) were all less than 1.5%,while the recurrence(RSD) was 0.65%(n=5).The limit of detection was 0.5μg/ml,the average recovery rates were 97.7%,97.2%,94.7% and 94.6%.ConclusionOur developed method can shorten the time used for Ginkgo biloba leaves pretreatment,and is a simple and reliable method to determine the content of ginkgolied A,B,C and Bilobalide in the Ginkgo biloba extract.The results also prove that the quality of Ginkgo biloba in Guizhou Province is relatively good.

Key concepts: Ginkgo biloba, Ginkgolides, Chromatography, Ginkgo, Chemistry, Ginkgoales, Detection limit, High-performance liquid chromatography

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