Clinical Significance of Serum Mitochondria Aspartate Aminotransferase in Patients with Various Kinds of Liver Diseases

Objective To explore the levels and clinical significance of serum mitochondria aspartate aminotransferase (m-AST) in patients with various kinds of liver diseases.Methods The levels of serum m-AST in patients with liver diseases were measured by using immunoinhibition assays and the levels in different disease stage were also analyzed.Results There was a significant increase of m-AST in acute hepatitis followed by chronic hepatitis and hepatitis cirrhosis,however,there was only light increase in hepatocarcinoma group.Two weeks treatment sharply decreased m-AST in acute hepatitis group (P 0.05) while in chronic hepatitis group,m-AST declined without statistic significance (P 0.05).There was no noted change in patients with liver cirrhosis or hepatocarcinoma after two weeks treatment.Conclusion m-AST is a useful marker for diagnosis,treatment assessing and prognosis judgment of various kinds of liver diseases.