Study on Clinical Value of Serum Aspartate Aminortransferase in Liver Diseases

Objective To study the changes and the clinical significance of serum mitochondrial aspartate aminotransferase(m-AST) in patients with different liver diseases. Methods The serum m-AST,ALT,AST,AKP,GGT,AFU,and 5'-NT of 123 patients with different liver diseases were measured by HITACHI 7170A auto Analyzer. Results In different states of patients,the serum level of m-AST increased in different degrees.The m-AST elevated significantly in acute hepatitis group.In the time of liver cirrhosis commutation,the m-AST change was not significant,but in the time of uncommutation,m-AST increased continuously.The AST and ALT increased in the patients with different liver diseases.AKP,GGT,and 5'-NT increased in the patients with hepatocarcinoma. Conclusions As a sensitive index in clinical diagnosis of liver damage,necrosis,and prognosis estimation,m-AST reflects the disease period in the chain of acute hepatitis,chronic hepatitis,hepatocirrhosis,and hepatocarcinoma.Therefore,m-AST is a valuable index in diagnosis disease,treatment guidance,and prognosis estimation.