Correlation between Serum Total Bile Acid and Fetal Prognosis in Patients with Pregnancy

Objective To explore the serum total bile acid and fetal prognosis in patients with intrahepatic cholestasis of pregnancy(ICP).Methods On the base of serum total bile acid,95 patients with ICP were divided into group A(50μmol/L)and group B(≥50μmol/L).The rate of premature delivery,intrauterine growth retardation(IUGR),fetal death,meconium-stained amniotic fluid,fetal distress and neonatal prognosis,and the relation between labor and fetal distress were analyzed retrospectively.[WTHZ]Results [WT]Premature delivery,fetal death,amniotic fluid with dung,fetal distress,neonatal asphyxia and neonatal abnormality in group A were increased significantly compared with group B(P0.05),butIUGR in group A was alike with group B(P0.05).After labor,patients amniotic fluid with dung,fetal distress were increased evidently compared with group B(P 0.05).[WTHZ]Conclusion [WT]Serum total bile acid is one of important factors to evaluate the fetal condition in uterus with intrahepatic cholestasis of pregnancy.