Correlation between serum total bile acid and perinatal infant prognosis in patients with intrahepatic cholestasis of pregnancy

Objective It is to study the correlation between the serum total bile acid and perinatal infant prognosis in patients with intrahepatic cholestasis of pregnancy (ICP).Methods Ninety-five patients with ICP were divided into group A (50 μmol/L) and group B (≥50 μmol/L). The difference of premature delivery, intrauterine growth retardation (IUGR), fetal death, meconium-stained amniotic fluid, fetal distress, neonatal prognosis and the relation between fetal distress, meconium-stained amniotic fluid and in labor of the two groups were analyzed retrospectively.Results The rates of premature delivery, fetal death, meconium-stained amniotic fluid, fetal distress, neonatal asphyxia and neonatal abnormality in group A were obviously higher than group B (P0.05), the rate of IUGR was no significant difference between the two groups(P0 05), the rates of fetal distress and meconium-stained amniotic fluid of patients with ICP after in labor were significant higher (P0.05).Conclusion Serum total bile acid is one of the important indexes which is used to pretest the fetal condition in uterus and its prognosis of patients with ICP. Perinatal infant prognosis is poor when serum total bile acid ≥50 μmol/L.