Anti-fatigue effect of siraitia grosvenorii fruit extracts on mice with exercise fatigue

Objective To discuss the anti-fatigue effects of siraitia grosvenorii fruit extracts(SGFE) on the mice with exercise fatigue and to provide basis for clinical application of SGFE.Methods 144 male ICR mice were randomly divided into control group(n=36),SGFE low dosage group(n=36),SGFE middle dosage group(n=36) and SGFE high dosage group(n=36).The mice in control group were received an oral administration of physiological saline in a volume of 1.0 mL,and the mice in other three groups were received 1.0 mL of SGFE(100,200 and 400 mg·kg-1,once a day) for 28 d.All mice were forced to swim for 15 min each day.After 28 d,the blood,liver and gastrocnemius were collected after forced swimming test,and the biochemical parameters related to fatigue,including blood lactic acid(BLA),blood urea nitrogen(BUN),liver glycogen,and muscle glycogen were measured.Results Compared with control group,the exhautive swimming time of the mice in SGFE low,middle and high dosage groups was prolonged(P0.05),but there were no significant differences between SGFE low dosage,middle dosage and high dosage groups(P0.05);the levels of BLA of mice in SGFE low dosage,middle dosage and high dosage groups were significantly lower than that in control group(P0.05),and the BLA levels showed a decreasing trend with the increase of SGFE in SGFE low,middle and high dosage groups.The levels of BUN of mice in SGFE middle and high dosage groups were significantly lower than that in control group(P0.05),but there was no significant difference between SGFE low dosage group and control group.The levels of liver glycogen and muscle glycogen of mice in SGFE low,middle and high dosage groups were significantly higher than that in control group(P0.05),and they showed a increasing trend with the increase of SGFE dosagein SGFE low,middle and high dosage groups.Conclusion SGFE has significant anti-fatigue effect on the mice with exercise fatigue.