Study on the role of coenzyme Q_(10) in alleviating physical fatigue of mice in different genders

Objective To study the alleviating physical fatigue function of coenzyme Q10in mice of different genders. Methods The female and male mice were divided into 4 groups respectively,the solvent control group( soybean oil) and the low, medium and high dose group( 0. 042 g / kg,0. 0 83 g / kg,0. 250 g / kg). Mice in dose groups were orally given coenzyme Q10 samples for 30 d. Then the load swimming time,hepatic glycogen level,serum urea and blood lactic acid levels after swimming were observed in these mice. Results The differences of load swimming time,blood lactic acid and serum urea nitrogen contents after swimming,hepatic glycogen contents in three dose groups and solvent control group had no statistical significance in female mice( P 0. 05). While compared to solvent control group,the load swimming time was significantly longer in medium dose group of male mice,the serum urea levels decreased significantly in medium and high dose groups of male mice after swimming,and the blood lactic acid levels and AUC in three dose groups of male mice decreased distinctly after 20 min swmming. Conclusion Coenzyme Q10has effect on alleviating physical fatigue in male mice,but not in female mice.