Clinical Significance of Serum Lipids,Lipoproteins and Apolipoproteins in the Patients with Coronary Heart Disease

Objective To study the change and discriminative function and diagnostic value of serum lipids,lipoproteins-cholesterol and apolipoproteins AI and B in coronary heart disease(CHD).Method Serum lipids,lipo-proteins-cholesterol and apolipoproteins were determined in 64 patients with CHD and 60 normal controls,and prepared with each other other and calculated.Result and Conclusion The patients with CHD had significantly lower serum levels of high density lipoprotein cholesterol(HDL-C) and its two major subfractions cholesterol(HDL2-C and HDL3-3),apolipoprotein AI(ApoAI) and LDL-C/Total cholesterol(TC),and significantly higher levels of TC(female),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),apolipoprotein B(ApoB),LDL-C/ HDL-C and ApoB/ApoAI than the normal controls(P0.05).It is further studied that the parallel tests of the three serum lipids which consisted of HDL-C,TC and TG had applicable value for CHD diagnosis,instead of the five serum lipids which consisted of HDL-C,LDL-C,VLDL-C,TC and TG.And the parallel tests,which were made up of the five serum lipids plus HDL2-C and HDL3-C,ApoAI and ApoB,or HDL2-C,HDL3-C,ApoAI and ApoB,were quite better than the three serum lipids and satisfactory for CHD diagnosis.