Plasma lipid,lipoprotein and apolipoprotein concentration in coronary heart disease patients without hyperlipidemia

Objective To study condition of lipid metabolism in coronary heart disease(CHD) patients without hyperlipidemia. Methods The levels of plasma triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL C) and its subfractions(HDL 2 C,HDL 3 C) were measured by enzymology way,the levels of HDL C/TC and low density lipoprotein cholesterol(LDL C) were calculated,and apoAⅠ,apoB 100 concentration and lipoprotein(a)[LP(a)] were determined by an enzyme linked immunoassay(ELISA)in patients with CHD( n =50)and healthy subjects( n =30)of TC6.0 mmol/L and TG2.0 mmol/L. Results The levels of plasma TG,TC and LP(a) were higher in patients than in controls( P 0.05, P 0.01 and P 0 002 5,respectively),but their HDL C,HDL 3 C and HDL C/TC concentration was significantly lower than those of controls ( P 0 05, P 0 01, P 0 002 5,respectively).The levels of apoA Ⅰ/apoB 100 had not statistical different between both. Conclusion Abnormality of lipids,lipoproteins metabolism in CHD patients without hyperlipidemia is inherent.Decreased HDL C/TC,HDL C and HDL 3 C concentration is a main risk factor,but elevated LP(a) content is not ignored. Adjusting treatment of lipids is of a very important significance.