Clinical value of non-HDL-cholesterol in coronary heart disease diagnoses

Objective To investigate the clinical value of non-high-density lipoprotein cholesterol(non-HDL-C) and apolipoprotein B(apoB) in patients with coronary heart disease(CHD). Methods The concentrations of serum triglyceride(TG),total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), apolipoprotein A1(apoA1) and apoB in 118 patients with CHD were detected. Non-HDL-C levels and apoB/apoA1 ratios were calculated. All the results were analyzed with statistical methods. Results The concentrations of serum TG, non-HDL-C and the ratio of apoB/apoA1 in patients with CHD were significantly higher than those of healthy people(P0.01), while HDL-C and apoA1 were lower(P0.01).Serum HDL-C and apoA1 have higher diagnostic sensitivity in CHD than serum TC and LDL-C, while serum non-HDL-C, apoB and apoB/apoA1 had higher specificity. Conclusions Serum non-HDL-C and apoB/apoA1 have positive correlation with CHD and their early warning value are better than serum LDL-C and TC. In patients with normal serum LDL-C and TC, controlling their serum non-HDL-C and apoB will have more significance in prevention of CHD.