Simultaneous determination of borneol and other three sesquiterpenes in Baofukang suppository by capillary GC

Objective To establish a GC-FID method of Baofukang Suppository and develop this method for determination of borneol,furanodiene,curcumol and curdione at the same time.Methods A HP-5 quartz capillary column(30 m×0.25 mm,0.25 μm) programmed temperature was used at the flow rate of 2.5 mL · min-1 with split ratio of 10∶ 1;injection volume was 1 μL.Results Borneol,furanodiene,curcumol and curdione were linear in the range of 28.0-224.0(r=0.999 8),16.0-128.0(r=0.999 9),2.8-22.4(r=0.999 8),4.0-32.0 mg · L-1(r=0.999 9),the average recoveries were 103.7%,91.6%,102.5%,99.5%,RSD were 4.7%,3.6%,3.9%,4.3%(n=9),respectively.Conclusions The validated method is simple and shows good accuracy and repeatability,which can provide scientific evidence for the quality control of Baofukang Suppository.