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2010•Chinese Journal of Clinical Rational Drug UseRequires access

Clinical study of quetiapine and risperidone in the treatment of schizophrenia

Hou Zhan-lin

Open publisher page 3 citations

Abstract

Objective To explore the effect and adverse reactions of quetiapine in the treatment of schizophrenia. Methods 90 schizophrenics who met schizophrenia were randomly diveded into the quetiapine(n = 45)and risperidone(n = 45)groups. Curative effects were assessed with the positive and negative rating scale(PANSS),and side effects with the treatment emergent symptom scale(TESS)before treatment and at the ends of 1st,2nd,4th and 8th week of treatment. Results The effective rate of qutiapine group was 75. 6% higher than 73. 3% in risperidone group,which showed no significant difference (P 0. 05). Extrapyramidal side effects of quetiapine group were fewer than those of risperidone group (P 0. 05),there was no obvious difference in other factors of side effects between the 2 groups(P 0. 05). Conclusion Quetiapine has better curative effect,fewer adverse reactions and better compliance in the treatment of schizophrenia.

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Objective To explore the effect and adverse reactions of quetiapine in the treatment of schizophrenia. Methods 90 schizophrenics who met schizophrenia were randomly diveded into the quetiapine(n = 45)and risperidone(n = 45)groups. Curative effects were assessed with the positive and negative rating scale(PANSS),and side effects with the treatment emergent symptom scale(TESS)before treatment and at the ends of 1st,2nd,4th and 8th week of treatment. Results The effective rate of qutiapine group was 75. 6% higher than 73. 3% in risperidone group,which showed no significant difference (P 0. 05). Extrapyramidal side effects of quetiapine group were fewer than those of risperidone group (P 0. 05),there was no obvious difference in other factors of side effects between the 2 groups(P 0. 05). Conclusion Quetiapine has better curative effect,fewer adverse reactions and better compliance in the treatment of schizophrenia.

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Available abstract

Objective To explore the effect and adverse reactions of quetiapine in the treatment of schizophrenia. Methods 90 schizophrenics who met schizophrenia were randomly diveded into the quetiapine(n = 45)and risperidone(n = 45)groups. Curative effects were assessed with the positive and negative rating scale(PANSS),and side effects with the treatment emergent symptom scale(TESS)before treatment and at the ends of 1st,2nd,4th and 8th week of treatment. Results The effective rate of qutiapine group was 75. 6% higher than 73. 3% in risperidone group,which showed no significant difference (P 0. 05). Extrapyramidal side effects of quetiapine group were fewer than those of risperidone group (P 0. 05),there was no obvious difference in other factors of side effects between the 2 groups(P 0. 05). Conclusion Quetiapine has better curative effect,fewer adverse reactions and better compliance in the treatment of schizophrenia.

Key concepts: Quetiapine, Risperidone, Medicine, Schizophrenia (object-oriented programming), Negative symptom, Extrapyramidal symptoms, Internal medicine, Adverse effect

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